Boron tribromide → 4-(4-Chlorophenoxy)phenol

HRID 1909621Notes

Reaction equation

HRID 1909621 reaction equation
B(Br)(Br)Br.C[O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)=[CH:9][CH:8]=1>ClCCl>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][C:10]2[CH:11]=[CH:12][C:7]([OH:6])=[CH:8][CH:9]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 101054561-Chloro-4-(4-methoxyphenoxy)benzene

Product 1

HCID 123461204-(4-Chlorophenoxy)phenolYield 52.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the general procedure for Example 12 (step 2), boron tribromide (1.0 M solution in dichloromethane, 9.66 mL, 9.66 mmol) was added to the product from step 1 (0.76 g, 3.22 mmol) in dichloromethane (15 mL) to afford the title compound (0.37 g, 52%) as a light-green solid.

Sources & evidence

ORD record
ord-fd2e8167efb84ae6b0183cf50c0f2acf
Source dataset
uspto-grants-2013_12
Patent number
US08598359B2

Reaction notes

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