反应详情

温度

55 °C

To the product from Example 60 (37 mg, 0.0885 mmol) in 1,4-dioxane (1.5 mL) was added 12N HCl (1 mL) and the resulting mixture was stirred at 55° C. for 5 h. The solvent was removed in vacuo to obtain the product as a solid. The oil was triturated with diethyl ether (4 mL) to obtain the product as a creamish red solid. (39 mg, 99%): MS; m/z 404 (M+H): LCMS (UV) 94%; 1H NMR (400 MHz, DMSO-d6) δ 1.54-1.57 (m, 1H), 1.80-1.96 (m, 5H), 2.32-2.36 (m, 2H), 3.12-3.22 (m, 3H), 3.37-3.41 (m, 3H), 3.60-3.64 (m, 1H), 4.25-4.35 (m, 2H), 6.94 (d, 2H, J=6.8 Hz), 7.06 (s, 4H), 7.4 (d, 2H, J=6.4 Hz), 10.15 (s, 1H), 12.3 (s, 1H).

1. customThe solvent was removed in vacuo