4-Bromoanisole → 2-(4-Methoxy-phenyl)-thiazole

HRID 1909820Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Br[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1>>[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([C:2]2[S:1][CH:5]=[CH:4][N:3]=2)=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 77304-Bromoanisole

HCID 9256Thiazole

Product 1

HCID 112984492-(4-Methoxy-phenyl)-thiazoleYield 67%

Procedure

The title compound was prepared from thiazole (2.0 g, 24 mmol) and 4-bromoanisole (3.0 g, 16 mmol) using the procedure of Example 146, step 1 with 67% yield (2.0 g).

Sources & evidence

ORD record: ord-84312f5ee70f481eab836d013e2c0439
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598359B2

Reaction notes

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