Hydrochloric Acid → HCID 178499561, compound

HRID 1910144Notes

Reaction equation

HRID 1910144 reaction equation
[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[N:4]=[CH:3]1.Cl.O1CCOC[CH2:13]1>CO>[ClH:1].[CH3:13][O:9][C:8](=[O:10])[CH2:7][C:5]1[N:4]=[CH:3][NH:2][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178479752HCID 178479752, compound

Product 1

HCID 178499561HCID 178499561, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4.9 g (29.4 mmol) of (1H-imidazol-4-yl)-acetic acid hydrochloride, 4 N HCl in dioxane (22.5 mL) and methanol (70 mL) was refluxed overnight. Evaporation of the solvents gave (1H-imidazol-4-yl)-acetic acid methyl ester hydrochloride. LCMS: 141 (M+1)+.

Workup

  1. temperaturewas refluxed overnight
  2. customEvaporation of the solvents

Sources & evidence

ORD record
ord-c16ee8e14ab249ea9896ad9fbc26dbed
Source dataset
uspto-grants-2013_12
Patent number
US08598353B2

Reaction notes

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