Dimethylformamide → 2-(4-Fluoro-phenyl)-5-iodo-6-[methanesulfonyl-(3-methanesulfonyl-propyl)-amino]-furo[2,3-b]pyridine-3-carboxylic acid methylamide

HRID 191018Notes

Reaction equation

HRID 191018 reaction equation
[C:35](=[O:36])([O-:37])[O-:38].[CH3:1][NH:2][C:3](=[O:4])[c:5]1[c:6](-[c:20]2[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]2)[o:7][c:8]2[n:9][c:10]([NH:15][S:16](=[O:17])(=[O:18])[CH3:19])[c:11]([I:14])[cH:12][c:13]12.[Cs+:39].[Cs+:40].[I-:41].[I:27][CH2:28][CH2:29][CH2:30][S:31](=[O:32])(=[O:33])[CH3:34].[O:42]=[CH:43][N:44]([CH3:45])[CH3:46]>>[CH3:1][NH:2][C:3](=[O:4])[c:5]1[c:6](-[c:20]2[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]2)[o:7][c:8]2[n:9][c:10]([N:15]([S:16](=[O:17])(=[O:18])[CH3:19])[CH2:28][CH2:29][CH2:30][S:31](=[O:32])(=[O:33])[CH3:34])[c:11]([I:14])[cH:12][c:13]12

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 30165Iodide IonHCID 104967Cesium cation2×HCID 580523242-(4-fluorophenyl)-5-iodo-N-methyl-6-(methylsulfonamido)furo[2,3-b]pyridine-3-carboxamideHCID 580525411-Iodo-3-methanesulfonylpropane

Product 1

HCID 580523692-(4-Fluoro-phenyl)-5-iodo-6-[methanesulfonyl-(3-methanesulfonyl-propyl)-amino]-furo[2,3-b]pyridine-3-carboxylic acid methylamide

Sources & evidence

ORD record
ord-5656299f37e34a0095f56f40a4b6bf53
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…