2,6-Difluoro-3-nitrobenzoic acid → HCID 20098309, compound

HRID 1910236Notes

Reaction equation

HRID 1910236 reaction equation
F[C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([F:14])[C:3]=1[C:4]([OH:6])=[O:5].C([O-])(=O)C.[NH4+:19]>CO>[NH2:19][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([F:14])[C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 3026292,6-Difluoro-3-nitrobenzoic acidHCID 517165Ammonium Acetate

Product 1

HCID 20098309HCID 20098309, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.0 g (9.9 mmol) of 2,6-difluoro-3-nitro-benzoic acid in methanol and 3.0 g (30.0 mmol) of ammonium acetate was stirred at room temperature for 12 h. The solvent was evaporated and dilute HCl solution was added. The precipitated solid was collected by filtration and washed with water to produce 2-amino-6-fluoro-3-nitro-benzoic acid. LCMS: 201 (M+1)+.

Workup

  1. customThe solvent was evaporated
  2. additiondilute HCl solution was added
  3. filtrationThe precipitated solid was collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-65024298024b4fe29317d2ca55df3110
Source dataset
uspto-grants-2013_12
Patent number
US08598353B2

Reaction notes

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