Sodium Methoxide → HCID 10536492, compound

HRID 1910237Notes

Reaction equation

HRID 1910237 reaction equation
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7](F)[C:3]=1[C:4]([OH:6])=[O:5].[CH3:15][O-:16].[Na+]>CO>[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([O:16][CH3:15])[C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 20098309HCID 20098309, compound

Product 1

HCID 10536492HCID 10536492, compoundYield 83.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.8 g (9.0 mmol) of 2-amino-6-fluoro-3-nitro-benzoic acid in methanol and 2.9 g (54 mmol) of NaOMe was heated at 90° C. overnight to produce 1.6 g (7.5 mmol 83%) of 2-amino-6-methoxy-3-nitro-benzoic acid. LCMS: 213 (M+1)+.

Sources & evidence

ORD record
ord-cb1d8a4dad2e46cc89521666e05c23df
Source dataset
uspto-grants-2013_12
Patent number
US08598353B2

Reaction notes

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