HuagongsheHuagongshe Chemistry Print Report · For research reference only
Magnesium peroxide (Mg(O2)) → 4-Methyl-1-phenylisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Magnesium peroxide (Mg(O2)) | HCID 61745 | — |
| Reactant | 4-Methyl-1-phenyl-3,4-dihydroisoquinoline | HCID 13143580 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-Methyl-1-phenylisoquinoline | HCID 12843495 | 42.5% |
Reaction Steps
To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08603645B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-713ee148d584444f812fc7d9b29f8c64 |
| Source note | uspto-grants-2013_12 |