HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dimethoxyethane → 2-(Biphenyl-3-yl)-4-tert-butylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (3-Phenylphenyl)boronic acid | HCID 2734315 | — |
| Reactant | 2-Bromo-4-tert-butylpyridine | HCID 13183305 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(Biphenyl-3-yl)-4-tert-butylpyridine | HCID 59343985 | 90% |
Reaction Steps
15.0 g (0.7 mol) of 2-bromo-4-tert-butyl-pyridine was added to 13.8 g (0.7 mol) of 3-biphenylboronic acid, 2.4 g (0.002 mol) of Pd(Ph3)4, 26 g (0.188 mol) of K2CO3, 100 mL of DME and 100 mL of water. The reaction mixture was refluxed for 20 hours and separated on silica gel column with 10% ethyl acetate in hexane. ˜18.0 g (˜90% yield) 2-(biphenyl-3-yl)-4-tert-butylpyridine was obtained. MS confirmed the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08603645B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-a1af5b6d20e747c5b01f30c0c11f2b47 |
| Source note | uspto-grants-2013_12 |