反应详情

15.0 g (0.7 mol) of 2-bromo-4-tert-butyl-pyridine was added to 13.8 g (0.7 mol) of 3-biphenylboronic acid, 2.4 g (0.002 mol) of Pd(Ph3)4, 26 g (0.188 mol) of K2CO3, 100 mL of DME and 100 mL of water. The reaction mixture was refluxed for 20 hours and separated on silica gel column with 10% ethyl acetate in hexane. ˜18.0 g (˜90% yield) 2-(biphenyl-3-yl)-4-tert-butylpyridine was obtained. MS confirmed the desired product.

1. temperatureThe reaction mixture was refluxed for 20 hours
2. customseparated on silica gel column with 10% ethyl acetate in hexane