Benzyl 3-aminopyrrolidine-1-carboxylate → Benzyl 3-{[2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylthienopyrimidin-4-yl]amino}-pyrrolidine-1-carboxylate

HRID 1910460Notes

Reaction equation

HRID 1910460 reaction equation
[O:1]=[S:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][N:5]([C:13]2[NH:14][C:15](=O)[C:16]3[S:21][C:20]([CH3:22])=[CH:19][C:17]=3[N:18]=2)[CH2:4][CH2:3]1.[CH2:24]([O:31][C:32]([N:34]1[CH2:38][CH2:37][CH:36]([NH2:39])[CH2:35]1)=[O:33])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[O:1]=[S:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][N:5]([C:13]2[N:14]=[C:15]([NH:39][CH:36]3[CH2:37][CH2:38][N:34]([C:32]([O:31][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[O:33])[CH2:35]3)[C:16]3[S:21][C:20]([CH3:22])=[CH:19][C:17]=3[N:18]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 2756614Benzyl 3-aminopyrrolidine-1-carboxylateHCID 1363597882-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylthieno[3,2-d]pyrimidin-4(3H)-one

Product 1

HCID 86680739Benzyl 3-{[2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylthienopyrimidin-4-yl]amino}-pyrrolidine-1-carboxylate

Procedure

The title compound was prepared in analogy to Example 3-1 in Scheme 3 by using 2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylthieno[3,2-d]pyrimidin-4(3H)-one and benzyl-3-amino-1-pyrrolidinecarboxylate. MS obsd. (ESI+) [(M+H)+] 548.

Sources & evidence

ORD record
ord-fa6c31ccc341467f823464af6a57d437
Source dataset
uspto-grants-2013_12
Patent number
US08604019B2

Reaction notes

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