反应详情

5-(2-Bromoacetyl)thiophene-2-carbonitrile (33.4 mg, 0.14 mmol) was added to a solution of (R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate (54 mg, 0.14 mmol, prepared as in example 1) in ethyl acetate (2 ml). The resulting solution was stirred at room temperature for two days, then 5-(2-bromoacetyl)thiophene-2-carbonitrile (3.4 mg, 0.015 mmol) was added, and the stirring was kept for additional 16 hours. Et2O was added and the precipitate was recovered by filtration to afford (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-(5-cyanothiophen-2-yl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide (68 mg).

1. waitthe stirring was kept for additional 16 hours
2. filtrationthe precipitate was recovered by filtration