反应详情

2-Chloro-1-phenylethanone (20.8 mg, 0.13 mmol) was added to a solution of (R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate (50 mg, 0.13 mmol, prepared as in example 1) in ethyl acetate (2 ml). The reaction was stirred at room temperature overnight, then the solvent was evaporated under vacuum. The residue was treated with Et2O (4 ml) and sonicated to obtain a solid, which was collected by suction filtration and purified by flash chromatography (DCM/MeOH=95/5), to obtain (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (37.2 mg).

1. customthe solvent was evaporated under vacuum
2. additionThe residue was treated with Et2O (4 ml)
3. customsonicated
4. customto obtain a solid, which
5. filtrationwas collected by suction filtration
6. custompurified by flash chromatography (DCM/MeOH=95/5)