Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Chloroacetyl)thiophene → 3-((Bis(4-chlorophenyl)methoxy)-carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Chloroacetyl)thiophene | HCID 2757925 | — |
| 반응물 | Bis(4-chlorophenyl)methyl quinuclidine-3-carboxylate | HCID 70925824 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-((Bis(4-chlorophenyl)methoxy)-carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride | HCID 86672944 | 52.8% |
반응 단계
To a solution of bis(4-chlorophenyl)methyl quinuclidine-3-carboxylate (45 mg, 0.11 mmol, prepared as in example 6) in EtOAc (1.6 ml), 2-chloro-1-(thiophen-2-yl)ethanone (20.0 mg, 0.13 mmol) was added. The reaction was stirred at room temperature for 16 hours. Solvent was removed, and the crude was purified by preparative HPLC to afford 3-((bis(4-chlorophenyl)methoxy)-carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (16 mg, racemic mixture).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08604015B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-e6c122cd3ca0450da188b0294fb5f96c |
| 출처 메모 | uspto-grants-2013_12 |