反应详情

To a solution of bis(4-chlorophenyl)methyl quinuclidine-3-carboxylate (45 mg, 0.11 mmol, prepared as in example 6) in EtOAc (1.6 ml), 2-chloro-1-(thiophen-2-yl)ethanone (20.0 mg, 0.13 mmol) was added. The reaction was stirred at room temperature for 16 hours. Solvent was removed, and the crude was purified by preparative HPLC to afford 3-((bis(4-chlorophenyl)methoxy)-carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (16 mg, racemic mixture).

1. customSolvent was removed
2. customthe crude was purified by preparative HPLC