反应详情

To a solution of 3-fluorobenzyl quinuclidine-4-carboxylate (41 mg, 0.16 mmol) dissolved in EtOAc (2 ml), 2-chloro-1-(thiophen-2-yl)ethanone (20.0 mg, 0.12 mmol) was added. The reaction was stirred at room temperature for three days, and then the precipitate was collected by suction filtration to obtain 4-((3-fluorobenzyloxy)carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (30 mg, 45.4% yield).

1. filtrationthe precipitate was collected by suction filtration