反应详情

2-(2-Chloro-5-nitrophenyl)-oxazole (0.366 g, 1.63 mmol) was heated in N-methylpiperazine (15 mL) at reflux for 5 hrs. The mixture was allowed to cool and excess N-methylpiperazine was distilled under high vacuum. The residue was diluted with water and extracted with ethyl acetate. The organic phase was washed with water then brine, dried over sodium sulfate, filtered and concentrated. Drying under high vacuum gave 1-methyl-4-(4-nitro-2-oxazol-2-yl-phenyl)-piperazine (0.328 g, 70%) as a solid.

1. temperatureat reflux for 5 hrs
2. temperatureto cool
3. distillationexcess N-methylpiperazine was distilled under high vacuum
4. additionThe residue was diluted with water
5. extractionextracted with ethyl acetate
6. washThe organic phase was washed with water
7. dry with materialbrine, dried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. customDrying under high vacuum