反应详情

2-Hydroxy-4-nitro-benzoic acid tetrahydro-pyran-4-yl ester (0.32 g, 1.20 mmol) was hydrogenated in ethanol (25 mL) with 10% palladium on charcoal catalyst (70 mg) until hydrogen uptake ceased. The mixture was filtered through Celite and concentrated to give a residue which was purified by flash column chromatography on silica, eluting with ethyl acetate/petroleum ether (5-35% gradient) to give 4-amino-2-hydroxy-benzoic acid tetrahydro-pyran-4-yl ester (100 mg, 35%).

1. filtrationThe mixture was filtered through Celite
2. concentrationconcentrated
3. customto give a residue which
4. customwas purified by flash column chromatography on silica
5. washeluting with ethyl acetate/petroleum ether (5-35% gradient)