反应详情

A solution of 1-(4-aminophenyl)-4-piperidone (300 mg, 1.58 mmol) and methoxylamine hydrochloride (250 mg, 3.0 mmol) in methanol (5 mL) was heated at reflux for 30 min. The solvent was evaporated, water added and extracted with ethyl acetate. The combined organic layers were washed with water and brine then dried over sodium sulfate. Concentration to dryness afforded 1-(4-amino-phenyl)-piperidin-4-one O-methyl-oxime (220 mg, 64%) as a semisolid.

1. temperatureat reflux for 30 min
2. customThe solvent was evaporated
3. additionwater added
4. extractionextracted with ethyl acetate
5. washThe combined organic layers were washed with water and brine
6. dry with materialthen dried over sodium sulfate
7. concentrationConcentration to dryness