3(2H)-Pyridazinone → 4-(6-Oxo-1,6-dihydropyridazin-3-yl)benzonitrile

HRID 1910853Notes

Reaction equation

[C:1]([C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1)(=O)[CH3:2].[N:12]1[NH:13][C:14](=[O:18])[CH:15]=CC=1>>[O:18]=[C:14]1[NH:13][N:12]=[C:1]([C:4]2[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=2)[CH:2]=[CH:15]1

Participants

Reactant 2

HCID 681533(2H)-Pyridazinone

HCID 740444'-Cyanoacetophenone

Product 1

HCID 194194914-(6-Oxo-1,6-dihydropyridazin-3-yl)benzonitrile

Procedure

50 g of 4-acetylbenzonitrile is converted into the pyridazinone in accordance with GWP 1.

Sources & evidence

ORD record: ord-63e789d1859a423199853f31ba0e7fef
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08604036B2

Reaction notes

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