Hydrochloric Acid → HCID 46234224, compound

HRID 1911080Notes

Reaction equation

HRID 1911080 reaction equation
C(OC([N:8]1[CH2:36][CH2:35][C:11]2([C:15](=[O:16])[N:14]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][C@H:25]([N:28]5[CH2:32][CH2:31][CH2:30][C@@H:29]5[CH3:33])[CH2:24]4)=[CH:19][C:18]=3[CH3:34])[CH2:13][CH2:12]2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH3:34][C:18]1[CH:19]=[C:20]([N:23]2[CH2:27][CH2:26][C@H:25]([N:28]3[CH2:32][CH2:31][CH2:30][C@@H:29]3[CH3:33])[CH2:24]2)[CH:21]=[CH:22][C:17]=1[N:14]1[CH2:13][CH2:12][C:11]2([CH2:10][CH2:9][NH:8][CH2:36][CH2:35]2)[C:15]1=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46233719HCID 46233719, compound

Product 1

HCID 46234224HCID 46234224, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-[2-Methyl-4-((2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (150 mg) was treated with 1 mL (excess) of 4M HCl in dioxane at 0° C. The stirring was continued at rt for 1 h. The solvent was evaporated and the solid was further dried under high vacuum at rt for 2 h to obtain the title compound as a tan solid.

Workup

  1. customThe solvent was evaporated
  2. customthe solid was further dried under high vacuum at rt for 2 h

Sources & evidence

ORD record
ord-e7051b25732e40c6bf79ad799f015ae9
Source dataset
uspto-grants-2013_12
Patent number
US08604046B2

Reaction notes

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