Potassium Carbonate → HCID 59633880, compound

HRID 1911115Notes

Reaction equation

HRID 1911115 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][C:4]=1F)#[N:2].[C:23]([O-])([O-])=[O:24].[K+].[K+]>CO.O>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][C:4]=1[O:24][CH3:23])#[N:2]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 59633877HCID 59633877, compound

Product 1

HCID 59633880HCID 59633880, compoundYield 102%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
75 °C

Procedure

A solution of 95 mg (0.32 mmol) of compound 9m was combined with 120 mg (0.87 mmol) of K2CO3 in 8 mL of MeOH and heated at 75° C. for 5 h. The mixture was cooled, diluted with water, and extracted with CH2Cl2. The organic solution was concentrated to give 100 mg (100%) of 9n as a white solid.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted with CH2Cl2
  3. concentrationThe organic solution was concentrated

Sources & evidence

ORD record
ord-83b1821d6ef74ca5bc15da82d03af52f
Source dataset
uspto-grants-2013_12
Patent number
US08604017B2

Reaction notes

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