Methanol → 1-Cyclopropylpiperazine

HRID 1911391Notes

Reaction equation

HRID 1911391 reaction equation
Cl.Cl.[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1.CO>O>[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 887MethanolHCID 212208121-Cyclopropylpiperazine dihydrochloride

Product 1

HCID 47420041-Cyclopropylpiperazine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Cyclopropylpiperazine dihydrochloride (1.493 g, 7.5 mmol) was dissolved in water (5.00 mL) and methanol (5.00 mL) and converted to its freebase by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 3.5M ammonia in methanol and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine u) (0.796 g, 84%) as an oil.

Workup

  1. washThe desired product was eluted from the column
  2. customwere evaporated to dryness

Sources & evidence

ORD record
ord-dd58445ccf9f4d0da05495f89cdcfc07
Source dataset
uspto-grants-2013_12
Patent number
US08604022B2

Reaction notes

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