Phenylboronic Acid → HCID 86623842, compound

HRID 1911532Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[C@@H:12]([CH:13]=[C:14]([Br:16])Br)[CH2:11][O:10][C:9]1([CH3:18])[CH3:17])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:19]1(B(O)O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:1]([O:5][C:6]([N:8]1[C@@H:12](/[CH:13]=[C:14](\[Br:16])/[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:11][O:10][C:9]1([CH3:18])[CH3:17])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 14756526HCID 14756526, compound

Product 1

HCID 86623842HCID 86623842, compound

Procedure

In analogy to example 162b (S)-4-(2,2-dibromo-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester was reacted with phenylboronic acid to give (S)-4-((Z)-2-bromo-2-phenyl-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester. Light yellow crystalline solid.

Sources & evidence

ORD record: ord-66de375464094c41ba40b2a7c075e52c
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08604061B2

Reaction notes

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