Formic Acid → HCID 68716891, compound

HRID 1911549Notes

Reaction equation

HRID 1911549 reaction equation
[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[C:12]([F:15])([F:14])[F:13])[C:3]#[N:4].[ClH:16].C(O)=[O:18]>>[ClH:16].[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[C:12]([F:15])([F:13])[F:14])[C:3]([NH2:4])=[O:18]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 68712687HCID 68712687, compound

Product 1

HCID 68716891HCID 68716891, compoundYield 25%

Procedure

A solution of (RS)-amino-(4-fluoro-2-trifluoromethyl-phenyl)-acetonitrile (4.47 g) in formic acid (15 ml) saturated with hydrogen chloride was stirred at room temperature for 90 min. The mixture was then concentrated in vacuo and the residue was resuspended in acetone whereby white crystals formed The crystals were collected by filtration, washed with acetone and dried in vacuo to afford (RS)-2-amino-2-(4-fluoro-2-trifluoromethyl-phenyl)-acetamide hydrochloride (1.40 g, 25%) as a white solid. MS (ISP): 273.1 ([M+H]+).

Workup

  1. concentrationThe mixture was then concentrated in vacuo
  2. customformed The crystals
  3. filtrationwere collected by filtration
  4. washwashed with acetone
  5. customdried in vacuo

Sources & evidence

ORD record
ord-d631cc096ba246c481fe269ca6decb37
Source dataset
uspto-grants-2013_12
Patent number
US08604061B2

Reaction notes

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