Methacrolein → HCID 87348033, compound

HRID 1911715Notes

Reaction equation

HRID 1911715 reaction equation
[CH2:1]([P:3]([O-:8])[O:4][CH2:5][CH2:6][OH:7])[CH3:2].[CH3:9][C:10](=[CH2:13])[CH:11]=[O:12].[O-]CC.[Na+]>>[CH2:1]([P:3]([CH2:9][CH:10]([CH3:13])[CH:11]=[O:12])(=[O:8])[O:4][CH2:5][CH2:6][OH:7])[CH3:2]

Participants

4

Reactant 3

HCID 6562MethacroleinHCID 2723922Sodium ethoxideHCID 131731078HCID 131731078, compound

Product 1

HCID 87348033HCID 87348033, compoundYield 88%

Procedure

A 500 ml five-neck flask equipped with thermometer, reflux condenser, high-performance stirrer and dropping funnel is initially charged with 63.5 g (0.46 mol) of 2-hydroxyethyl ethylphosponite (produced as in Example 4) and 32.2 g (0.46 mol) of 2-methyl-2-propenal. While stirring, 25 ml of sodium ethoxide (30% in ethanol) are added dropwise at such a rate that a reaction temperature of 60° C. becomes established. A slightly yellow-colored liquid is obtained. The crude product thus obtained is distilled in vacuo to obtain 84 g (88% of theory) of 2-hydroxyethyl ethyl(2-methyl-2-formylethyl)phosphinate as colorless liquid.

Workup

  1. customA 500 ml five-neck flask equipped with thermometer
  2. temperaturereflux condenser, high-performance stirrer
  3. customA slightly yellow-colored liquid is obtained
  4. customThe crude product thus obtained
  5. distillationis distilled in vacuo

Sources & evidence

ORD record
ord-5f4812291a2e4bf59d5a32a31d345903
Source dataset
uspto-grants-2013_12
Patent number
US08604108B2

Reaction notes

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