Methylamine → 1269615-30-6

HRID 1911844Notes

Reaction equation

HRID 1911844 reaction equation
Cl[CH2:2][C:3]1[N:4]=[N:5][N:6]([CH3:8])[N:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[N:5][N:6]([CH3:8])[N:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 122050815-chloromethyl-2-methyl-2H-tetrazole

Product 1

HCID 670586961269615-30-6

Conditions

Temperature
45 °C

Procedure

To 5-(chloromethyl)-2-methyl-2H-tetrazole (136.8 mg, 1.032 mmol), was added methylamine (4.00 mL of 2M solution in THF, 8.00 mmol). This was stirred for 16 hours at 45° C. A white precipitate formed in the reaction and it was allowed to continue stirring for another 24 hours at room temperature before being concentrated in vacuo and successively azeotroped with THF, triethylamine, methanol, and then DCM. 1H NMR (600 MHz, CDCl3) δ 2.23 (s, 3H), 3.80 (s, 2H), 4.29 (s, 3H).

Workup

  1. customA white precipitate formed in the reaction and it
  2. stirringto continue stirring for another 24 hours at room temperature
  3. concentrationbefore being concentrated in vacuo
  4. customsuccessively azeotroped with THF, triethylamine, methanol

Sources & evidence

ORD record
ord-0bcd22bebf4d40928a69a85fd30ac9f7
Source dataset
uspto-grants-2013_12
Patent number
US08604038B2

Reaction notes

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