Hydrogen Bromide → HCID 44599974, compound

Participants

Reaction Conditions

Reaction Steps

Aqueous hydrogen bromide (15 mL) was added to a reaction vessel containing sorafenib free base (3.0 g) and the reaction mixture was stirred for about 5 minutes. Temperature was raised to about 70° C. The reaction mixture was stirred for about 2 hours. Solid precipitated out. The reaction mixture was concentrated and purified by adding toluene (3×15 mL) and concentrated to obtain a solid. Ethanol (2 mL) was added. The reaction mixture was stirred for about 5 minutes followed by addition of diisopropyl ether (5 mL). The solid was filtered and dried at about 50° C. for about 12 hours to obtain sorafenib hydrobromide.

Provenance & Evidence