反应详情

温度

70 °C

Aqueous hydrogen bromide (15 mL) was added to a reaction vessel containing sorafenib free base (3.0 g) and the reaction mixture was stirred for about 5 minutes. Temperature was raised to about 70° C. The reaction mixture was stirred for about 2 hours. Solid precipitated out. The reaction mixture was concentrated and purified by adding toluene (3×15 mL) and concentrated to obtain a solid. Ethanol (2 mL) was added. The reaction mixture was stirred for about 5 minutes followed by addition of diisopropyl ether (5 mL). The solid was filtered and dried at about 50° C. for about 12 hours to obtain sorafenib hydrobromide.

1. stirringThe reaction mixture was stirred for about 2 hours
2. customSolid precipitated out
3. concentrationThe reaction mixture was concentrated
4. custompurified
5. additionby adding toluene (3×15 mL)
6. concentrationconcentrated
7. customto obtain a solid
8. stirringThe reaction mixture was stirred for about 5 minutes
9. filtrationThe solid was filtered
10. customdried at about 50° C. for about 12 hours