Benzaldehyde → HCID 178434292, compound

HRID 1911899Notes

Reaction equation

HRID 1911899 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7](C(=O)C(C)(C)C)[N:6]=[C:5]2[CH3:17].O=[C:19]1[CH2:24][CH2:23][CH2:22][N:21]([C:25](OC(C)(C)C)=O)[CH2:20]1.C(=O)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH2:25]([N:21]1[CH2:20][CH2:19][CH2:24][CH:23]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][N:6]=[C:5]3[CH3:17])[CH2:22]1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

4

Reactant 3

HCID 240BenzaldehydeHCID 2756825Tert-butyl 3-oxopiperidine-1-carboxylateHCID 66760997HCID 66760997, compound

Product 1

HCID 178434292HCID 178434292, compound

Procedure

The title compound was prepared by reaction of 1-(5-amino-3-methyl-1H-indazol-1-yl)-2,2-dimethylpropan-1-one with tert-butyl 3-oxopiperidine-1-carboxylate using the method of Example 3, deprotection using the method of Example 4, reaction with benzaldehyde following the method of Example 8, and final deprotection using the method of Example 9.

Sources & evidence

ORD record
ord-ff661d403da747a39503218f79f66130
Source dataset
uspto-grants-2013_12
Patent number
US08604205B2

Reaction notes

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