Benzaldehyde → HCID 57446073, compound

HRID 1911901Notes

Reaction equation

[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.O=[C:13]1[CH2:19][CH2:18][CH2:17][N:16]([C:20](OC(C)(C)C)=O)[CH2:15][CH2:14]1.C(=O)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:20]([N:16]1[CH2:15][CH2:14][CH2:13][CH:19]([NH:11][C:6]2[C:5]3[CH:4]=[CH:3][N:2]=[CH:1][C:10]=3[CH:9]=[CH:8][CH:7]=2)[CH2:18][CH2:17]1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

Reactant 3

HCID 240Benzaldehyde

HCID 707665-Aminoisoquinoline

HCID 1512679N-Boc-hexahydro-1H-azepin-4-one

Product 1

HCID 57446073HCID 57446073, compound

Procedure

The title compound was prepared by reaction of isoquinolin-5-amine with tert-butyl 4-oxoazepane-1-carboxylate using the method of Example 3, followed by deprotection using the method of Example 4 and reaction with benzaldehyde following the method of Example 8.

Sources & evidence

ORD record: ord-6913372eb0e842dc948e703409e0156a
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08604205B2

Reaction notes

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