Phenylboronic Acid → HCID 68193673, compound

HRID 1911924Notes

Reaction equation

[C:1](=[O:26])([O:7][C:8]1[N:12]([C:13]2[N:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:11]=[C:10]([C:19]2[CH:24]=[CH:23][C:22](I)=[CH:21][CH:20]=2)[CH:9]=1)[O:2][C:3]([CH3:6])([CH3:5])[CH3:4].[C:27]1(B(O)O)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[C:1](=[O:26])([O:2][C:3]([CH3:6])([CH3:5])[CH3:4])[O:7][C:8]1[N:12]([C:13]2[N:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:11]=[C:10]([C:19]2[CH:24]=[CH:23][C:22]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:21][CH:20]=2)[CH:9]=1

Participants

Reactant 2

HCID 66827Phenylboronic Acid2×

HCID 51038616HCID 51038616, compound

Product 1

HCID 68193673HCID 68193673, compoundYield 95%

Procedure

The title compound was prepared in the same manner as in Example C-1, except that an equimolar amount of each of 3-(4-iodophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl tert-butyl carbonate (25) prepared in Example B-6 and phenylboronic acid (manufactured by Aldrich) was used in place of Compound 21 prepared in Example B-2 and phenylboronic acid.

Sources & evidence

ORD record: ord-3a5bd7602ac643e5abe4197c005c2eb5
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08604210B2

Reaction notes

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