Acetic Acid → HCID 86230360, compound

HRID 1911945Notes

Reaction equation

HRID 1911945 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][CH:12]=2)=[N:8][CH:9]=1)([O-])=O.C(O)(=O)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>N1C=CC=CC=1.[Zn].[O-2].[O-2].[Mn+4]>[CH:17]([C:14]1[CH:15]=[CH:16][C:11]([O:10][C:7]2[N:8]=[CH:9][C:4]([NH:1][S:24]([CH3:23])(=[O:26])=[O:25])=[CH:5][CH:6]=2)=[CH:12][CH:13]=1)=[O:18]

Participants

7

Reactant 3

HCID 176Acetic AcidHCID 31297Methanesulfonyl chlorideHCID 17604338HCID 17604338, compound

Product 1

HCID 86230360HCID 86230360, compound

Reagents, catalysts & solvents 3

HCID 23994ZincCatalystHCID 178418406HCID 178418406, compoundCatalystHCID 1049PyridineSolvent

Procedure

{4-[(5-nitropyridin-2-yl)oxy]phenyl}methanol was subjected to reduction of nitro group by using zinc and acetic acid, the obtained compound reacted with methanesulfonyl chloride in pyridine, and the obtained compound was subjected to oxidation by using manganese dioxide to give the title compound having the following physical data.

Sources & evidence

ORD record
ord-3b133b62177949dc939609ae450cb453
Source dataset
uspto-grants-2013_12
Patent number
US08604207B2

Reaction notes

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