反应详情

3-(2-Ethylbutyl)-1-cyclobutenecarboxylic acid (39.0 g) was dissolved in tetrahydrofuran (200 mL). To the solution was added 5 w/w % palladium on activated carbon (5.5 g). The mixture was stirred at RT overnight under hydrogen atmosphere (1 atm). The 5 w/w % palladium on activated carbon was filtered off using Celite and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (Eluent: ethyl acetate/hexane=1/4→1/2) to give the title compound (25.2 g).

1. filtrationwas filtered off
2. concentrationthe filtrate was concentrated in vacuo
3. customThe residue was purified by silica gel column chromatography (Eluent: ethyl acetate/hexane=1/4→1/2)