Hydrochloric Acid → 3-Isobutylcyclobutylamine hydrochloride

HRID 1912102Notes

Reaction equation

HRID 1912102 reaction equation
[CH2:1]([CH:5]1[CH2:8][CH:7]([NH:9]C(=O)OC(C)(C)C)[CH2:6]1)[CH:2]([CH3:4])[CH3:3].[ClH:17]>O1CCOCC1>[ClH:17].[CH2:1]([CH:5]1[CH2:8][CH:7]([NH2:9])[CH2:6]1)[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71135570tert-Butyl (3-isobutylcyclobutyl)carbamate

Product 1

HCID 866750563-Isobutylcyclobutylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

tert-Butyl (3-isobutylcyclobutyl)carbamate (2.90 g) and dioxane (15 mL) were mixed. To the mixture was added a solution of 4 N hydrochloric acid in dioxane (15 mL) at 10° C. The mixture was stirred at RT overnight. The reaction mixture was concentrated in vacuo to give the title compound (1.97 g) as a crude product.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1106295c842d4ad5bea490f4d03e1dd9
Source dataset
uspto-grants-2013_12
Patent number
US08604069B2

Reaction notes

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