N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine → HCID 131731085, compound

HRID 1912232Notes

Reaction equation

HRID 1912232 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4](=[O:6])N.N[C@H](C(O)=[O:16])C(C)C.[NH2:18][CH:19]([NH2:21])[CH3:20].[C:22]([C:26]1[C:27]([NH:29][C:30](=[O:32])[CH:31]=1)=[O:28])(=[O:25])[CH2:23][CH3:24].[NH:33](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:34]([C:39]([OH:41])=[O:40])[CH2:35][CH2:36][S:37][CH3:38]>>[NH2:33][C@H:34]([C:39]([OH:41])=[O:40])[CH2:35][CH2:36][S:37][CH3:38].[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:16])=[O:6].[NH2:18][CH:19]([NH2:21])[CH3:20].[C:22]([C:26]1[C:27]([NH:29][C:30](=[O:32])[CH:31]=1)=[O:28])(=[O:25])[CH2:23][CH3:24]

Participants

3

Reactant 2

HCID 2724632N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionineHCID 131731084Asparagine Valine diaminoethane propionyl-maleimide

Product 1

HCID 131731085HCID 131731085, compound

Procedure

AF-Methionine-(D)Aspartic Acid-diaminoethane-propionyl maleimide (7d) was prepared using the same method as 5c starting with 100 mg of Fmoc-(D)Asp(OtBu)-diaminoethane-trityl resin (3), and using Fmoc-Met as AA1. Yield: 19.4 mg (25%) of white solid. RP-HPLC analysis: >95% at 10.97 min; ESMS m/z=1185.195 (M+H)+.

Sources & evidence

ORD record
ord-dc6b3540b930492cbc76eb7db5ebbc36
Source dataset
uspto-grants-2013_12
Patent number
US08609105B2

Reaction notes

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