Thionyl Chloride → HCID 86665150, compound

HRID 1912510Notes

Reaction equation

HRID 1912510 reaction equation
[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10](O)=[O:11].S(Cl)([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10]([Cl:16])=[O:11]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 671611162-((1S,2S,5S)-6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)acetic acid

Product 1

HCID 86665150HCID 86665150, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
22 °C

Procedure

To a mixture of Example 1B (300 mg, 1.65 mmol) and thionyl chloride (901 μL, 12.4 mmol) was added a drop of dimethylformamide. The reaction was stirred at about 22° C. for 2 hours. The excess thionyl chloride was evaporated and the residue was dried under vacuum to afford the title compound.

Workup

  1. customThe excess thionyl chloride was evaporated
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-4406a30cc25e48f1883537dfb684f406
Source dataset
uspto-grants-2013_12
Patent number
US08609674B2

Reaction notes

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