反应详情

温度

100 °C

The compound from step 3 (12.78 g, 0.05 mol) was dissolved in (4:1:1) PhMe/H2O/DME (111 ml). Pd(Ph3P)4 (2.9 g, 0.05 eq), K2CO3, and p-tolylboronic acid (6.81 g, 1 eq) were added, the mixture was degassed and heated at 100° C. overnight. After cooling to room temperature the organic layer was purified by silica gel chromatography (0-10% EtOAc in hexane) to give 5.5 g of the title compound.

1. customthe mixture was degassed
2. temperatureAfter cooling to room temperature the organic layer
3. customwas purified by silica gel chromatography (0-10% EtOAc in hexane)