HRID1912712

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@]12CCC(=O)CC1[C@@H](C#N)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12

HCID69133284

未命名化合物

$结构：CO/N=C1\CC2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC45OCCOC43OCCO5)[C@H]12$

HCID178502611

未命名化合物

PRODUCTS

生成物

$结构：CO/N=C1\CC2CC(=O)CC[C@]2(C)[C@H]2CC[C@]3(C)C(=O)CC[C@H]3[C@H]12$

HCID87654088

未命名化合物

收率 55%

PROCEDURE

实验过程

The title compound II-br was prepared in 55% yield from 3,3:17,17-bis(ethylendioxy)-7(E)-methoxyiminoandrostane by the procedure described above for the preparation of 6α-cyanoandrostane-3,17-dione (II-ac, Prepn. 3). The crude product was purified by flash chromatography (SiO2, n-hexane/EtOAc 6/4). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS: δ 3.72 (s, 3H), 2.89 (m, 1H), 2.63-0.93 (m, 19H), 1.12 (s, 3H), 0.82 (s, 3H).

WORKUP

后处理

customThe crude product was purified by flash chromatography (SiO2, n-hexane/EtOAc 6/4)