HRID1912715

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@]12CCC(=O)CC1[C@@H](C#N)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12

HCID69133284

未命名化合物

结构：C[C@]12CCCCC1C[C@@H](NC=O)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3

HCID86635590

未命名化合物

PRODUCTS

生成物

结构：C[C@]12CCC(=O)CC1C[C@@H](NC=O)[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12

HCID86651512

未命名化合物

收率 97%

PROCEDURE

实验过程

The title compound II-bu was prepared in 97% yield from 3,3:17,17-bis(ethylendioxy)-7α-formamidoandrostane by the procedure described above for the preparation of 6α-cyanoandrostane-3,17-dione (II-ac, Prepn. 3). The crude product was purified by flash chromatography (SiO2, n-hexane/acetone 70/30). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS: δ 8.18 (dd, 1H), 7.97 (d, 1H), 4.13 (m, 1H), 2.90-0.95 (m, 20H), 1.00 (s, 3H), 0.79 (s, 3H).

WORKUP

后处理

customThe crude product was purified by flash chromatography (SiO2, n-hexane/acetone 70/30)