Hydroxyamine hydrochloride → HCID 87709668, compound

Participants

Reaction Steps

The procedure described in Prepn. 20 was followed starting from 3β-(N-carbobenzyloxy-N-methyl-3-aminopropionyloxy)androstane-6,17-dione (0.70 g) and hydroxylamine hydrochloride. The residue was purified by flash chromatography (SiO2, n-hexane/acetone 60/40) to give the title compound (0.43 g, 60%). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 10.31 (1H, s), 7.30 (5H, m), 5.05 (2H, s), 4.56 (1H, m), 3.50-0.87 (27H, m), 0.78 (3H, s), 0.68 (3H, s).

Provenance & Evidence