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HRID1912751

反应详情

EQUATION

反应方程式

HRID 1912751 的结构方程式

REACTANTS

反应物

2
结构：Cl.NO
HCID443297

未命名化合物

结构：CN(CCC(=O)O[C@H]1CC[C@@]2(C)C(C1)C(=O)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12)C(=O)OCc1ccccc1
HCID69133363

未命名化合物

PRODUCTS

生成物

1
结构：CN(CCC(=O)O[C@H]1CC[C@@]2(C)C(C1)/C(=N/O)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12)C(=O)OCc1ccccc1
HCID87709668

未命名化合物

收率 60%

PROCEDURE

实验过程

The procedure described in Prepn. 20 was followed starting from 3β-(N-carbobenzyloxy-N-methyl-3-aminopropionyloxy)androstane-6,17-dione (0.70 g) and hydroxylamine hydrochloride. The residue was purified by flash chromatography (SiO2, n-hexane/acetone 60/40) to give the title compound (0.43 g, 60%). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 10.31 (1H, s), 7.30 (5H, m), 5.05 (2H, s), 4.56 (1H, m), 3.50-0.87 (27H, m), 0.78 (3H, s), 0.68 (3H, s).

WORKUP

后处理

  1. customThe residue was purified by flash chromatography (SiO2, n-hexane/acetone 60/40)