1,2-Difluoro-4-nitrobenzene → [1-(2-fluoro-4-nitrophenyl)-1H-indol-5-yl]carbamic acid tert-butyl ester

HRID 1912768Notes

Reaction equation

HRID 1912768 reaction equation
[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[CH:11]2)([CH3:4])([CH3:3])[CH3:2].[F:18][C:19]1[CH:20]=[C:21]([N+:26]([O-:28])=[O:27])[CH:22]=[CH:23][C:24]=1F>>[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[N:13]([C:24]1[CH:23]=[CH:22][C:21]([N+:26]([O-:28])=[O:27])=[CH:20][C:19]=1[F:18])[CH:12]=[CH:11]2)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 1230531,2-Difluoro-4-nitrobenzeneHCID 114589235-N-Boc-amino-1H-indole

Product 1

HCID 59725937[1-(2-fluoro-4-nitrophenyl)-1H-indol-5-yl]carbamic acid tert-butyl ester

Procedure

The title compound can be synthesized from (1H-indol-5-yl)carbamic acid tert-butyl ester and 3,4-difluoronitrobenzene in the same manner as in Step A of Example 1.

Sources & evidence

ORD record
ord-3ea0de1751ef48b6a2e9d0063d7435f7
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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