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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1912768Generated: November 2, 2026

1,2-Difluoro-4-nitrobenzene → [1-(2-fluoro-4-nitrophenyl)-1H-indol-5-yl]carbamic acid tert-butyl ester

https://huagongshe.com/reaction/1912768

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-Difluoro-4-nitrobenzeneHCID 123053—
Reactant5-N-Boc-amino-1H-indoleHCID 11458923—
Product[1-(2-fluoro-4-nitrophenyl)-1H-indol-5-yl]carbamic acid tert-butyl esterHCID 59725937—

Reaction Steps

The title compound can be synthesized from (1H-indol-5-yl)carbamic acid tert-butyl ester and 3,4-difluoronitrobenzene in the same manner as in Step A of Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08609656B2
Source datasetuspto-grants-2013_12
ORD IDord-3ea0de1751ef48b6a2e9d0063d7435f7
Source noteuspto-grants-2013_12