HRID1912774

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9590

1-Fluoro-4-nitrobenzene

C6H4FNO2

HCID2733265

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

C8H3ClF3NO

结构：CN(CCOc1cccc2[nH]ccc12)C(=O)OC(C)(C)C

HCID10708626

未命名化合物

PRODUCTS

生成物

结构：CN(CCOc1cccc2c1ccn2-c1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1)C(=O)OC(C)(C)C

HCID59725986

未命名化合物

PROCEDURE

实验过程

The title compound can be synthesized from [2-(1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl ester, 4-fluoronitrobenzene and 4-chloro-3-(trifluoromethyl)-phenyl isocyanate by using the same techniques as in Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a4b7ef790734533a67975216dec382f
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08609656B2
来源说明: uspto-grants-2013_12

反应 SMILES

[C:1]([O:5][C:6](=[O:21])[N:7]([CH2:9][CH2:10][O:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:13]=1[CH:14]=[CH:15][NH:16]2)[CH3:8])([CH3:4])([CH3:3])[CH3:2].F[C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-])=O)=[CH:25][CH:24]=1.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([N:39]=[C:40]=[O:41])=[CH:35][C:34]=1[C:42]([F:45])([F:44])[F:43]>>[C:1]([O:5][C:6](=[O:21])[N:7]([CH2:9][CH2:10][O:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:13]=1[CH:14]=[CH:15][N:16]2[C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:40]([NH:39][C:36]2[CH:37]=[CH:38][C:33]([Cl:32])=[C:34]([C:42]([F:44])([F:43])[F:45])[CH:35]=2)=[O:41])=[CH:25][CH:24]=1)[CH3:8])([CH3:4])([CH3:2])[CH3:3]