HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluoronitrobenzene → [2-(1-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | 1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene | HCID 2733265 | — |
| Reactant | [2-(1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl ester | HCID 10708626 | — |
| Product | [2-(1-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl ester | HCID 59725986 | — |
Reaction Steps
The title compound can be synthesized from [2-(1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl ester, 4-fluoronitrobenzene and 4-chloro-3-(trifluoromethyl)-phenyl isocyanate by using the same techniques as in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609656B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-9a4b7ef790734533a67975216dec382f |
| Source note | uspto-grants-2013_12 |