Bromomethylcyclopropane → tert-Butyl 4-{[6-bromo-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]sulfanyl}piperidine-1-carboxylate

HRID 191280Notes

Reaction equation

HRID 191280 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([S:13][CH:14]3[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]3)[cH:6][nH:7][c:8](=[O:12])[c:9]2[cH:10][cH:11]1.[CH:27]1([CH2:30][Br:31])[CH2:28][CH2:29]1>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([S:13][CH:14]3[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]3)[cH:6][n:7]([CH2:30][CH:27]3[CH2:28][CH2:29]3)[c:8](=[O:12])[c:9]2[cH:10][cH:11]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 67130258tert-Butyl 4-[(6-bromo-1-oxo-1,2-dihydroisoquinolin-4-yl)sulfanyl]piperidine-1-carboxylate

Product 1

HCID 86640974tert-Butyl 4-{[6-bromo-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]sulfanyl}piperidine-1-carboxylate

Sources & evidence

ORD record
ord-5b2d236ecbed4d6891118fda7d6a39e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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