(2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acid → HCID 178448325, compound

HRID 1912818Notes

Reaction equation

HRID 1912818 reaction equation
Cl.[NH2:2][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[N:5]=[CH:6][N:7]2[C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([C:29]([F:32])([F:31])[F:30])[CH:23]=2)=[O:20])=[CH:14][CH:13]=1.C(OC([NH:40][C@@H:41]([C:45](O)=O)[CH:42]([CH3:44])[CH3:43])=O)(C)(C)C>>[ClH:28].[NH2:40][C@H:41]([CH:42]([CH3:44])[CH3:43])[CH2:45][N-:2][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[N:5]=[CH:6][N:7]2[C:12]1[CH:13]=[CH:14][C:15]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([C:29]([F:31])([F:32])[F:30])[CH:23]=2)=[O:20])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 637605(2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acidHCID 231551201-[4-(6-Aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride

Product 1

HCID 178448325HCID 178448325, compound

Procedure

The titled compound can be synthesized from 1-[4-(6-amino-purin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride and tert-butoxycarbonyl-D-valine by using the same method as in Example 96.

Sources & evidence

ORD record
ord-b9071a86e64a4f0b91906a8b5df286c6
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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