53363-89-6 → HCID 86620273, compound

HRID 1912822Notes

Reaction equation

HRID 1912822 reaction equation
Cl.[NH2:2][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[N:5]=[CH:6][N:7]2[C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([C:29]([F:32])([F:31])[F:30])[CH:23]=2)=[O:20])=[CH:14][CH:13]=1.[CH3:33][N:34](C(OC(C)(C)C)=O)[C@H:35]([C:40](O)=[O:41])[CH2:36][CH:37]([CH3:39])[CH3:38]>>[ClH:28].[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([NH:21][C:19](=[O:20])[NH:18][C:15]2[CH:14]=[CH:13][C:12]([N:7]3[CH:6]=[N:5][C:4]4[C:8]3=[N:9][CH:10]=[N:11][C:3]=4[NH:2][C:40](=[O:41])[C@@H:35]([NH:34][CH3:33])[CH2:36][CH:37]([CH3:39])[CH3:38])=[CH:17][CH:16]=2)=[CH:23][C:24]=1[C:29]([F:31])([F:32])[F:30]

Participants

3

Reactant 2

HCID 701055553363-89-6HCID 231551201-[4-(6-Aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride

Product 1

HCID 86620273HCID 86620273, compound

Procedure

The title compound can be synthesized from 1-[4-(6-aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride and N-methyl-tert-butoxycarbonyl-L-leucine by using the same method as in Example 96.

Sources & evidence

ORD record
ord-37df33dee1794575ba303e6c22a46e0b
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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