Piperazine → HCID 23155164, compound

HRID 1912840Notes

Reaction equation

[Cl:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.F[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=1.[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]=[C:35]=[O:36])=[CH:30][C:29]=1[C:37]([F:40])([F:39])[F:38]>>[ClH:1].[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([NH:34][C:35]([NH:24][C:21]2[CH:22]=[CH:23][C:18]([N:6]3[CH:5]=[N:4][C:3]4[C:7]3=[N:8][CH:9]=[N:10][C:2]=4[N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:19][CH:20]=2)=[O:36])=[CH:30][C:29]=1[C:37]([F:38])([F:39])[F:40]

Participants

Reactant 4

HCID 4837Piperazine

HCID 9590p-Fluoronitrobenzene

HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzene

HCID 53592776-Chloropurine

Product 1

HCID 23155164HCID 23155164, compound

Procedure

The title compound can be synthesized from 6-chloropurine, piperazine, 4-fluoronitrobenzene and 4-chloro-3-(trifluoromethyl)phenyl isocyanate by using the same techniques as in Example 35.

Sources & evidence

ORD record: ord-873821ca356a403badbcc95428b9c3d0
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609656B2

Reaction notes

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